5LHU

ATP Phosphoribosyltransferase from Mycobacterium tuberculosis in complex with the allosteric inhibitor L-Histidine

Summary for 5LHU

Entry DOI	10.2210/pdb5lhu/pdb
Descriptor	ATP phosphoribosyltransferase, HISTIDINE, SULFATE ION, ... (5 entities in total)
Functional Keywords	atp-prtase, act, his g, histidine biosynthesis, transferase
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	1
Total formula weight	32510.66
Authors	de Chiara, C.,Pisco, J.P.,de Carvalho, L.P.,Smerdon, S.J.,Walker, P.A.,Ogrodowicz, R. (deposition date: 2016-07-12, release date: 2017-06-21, Last modification date: 2024-01-10)
Primary citation	Pisco, J.P.,Chiara, C.,Pacholarz, K.J.,Garza-Garcia, A.,Ogrodowicz, R.W.,Walker, P.A.,Barran, P.E.,Smerdon, S.J.,Carvalho, L.P.S. Uncoupling conformational states from activity in an allosteric enzyme. Nat Commun, 8:203-203, 2017 Cited by PubMed: 28781362 DOI: 10.1038/s41467-017-00224-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.02 Å)

Structure validation