5LHR

The catalytic domain of murine urokinase-type plasminogen activator in complex with the active site binding inhibitory nanobody Nb22

Summary for 5LHR

Entry DOI	10.2210/pdb5lhr/pdb
Descriptor	Urokinase-type plasminogen activator, Camelid-Derived Antibody Fragment Nb22 (3 entities in total)
Functional Keywords	trypsin-like serine proteases, nanobody, inhibitor, hydrolase
Biological source	Mus musculus (House Mouse) More
Cellular location	Secreted: P06869
Total number of polymer chains	2
Total formula weight	42816.83
Authors	Kromann-Hansen, T.,Lange, E.L.,Sorensen, H.P.,Ghassabeh, G.H.,Huang, M.,Jensen, J.K.,Muyldermans, S.,Declerck, P.J.,Andreasen, P.A. (deposition date: 2016-07-12, release date: 2017-06-28)
Primary citation	Kromann-Hansen, T.,Louise Lange, E.,Peter Srensen, H.,Hassanzadeh-Ghassabeh, G.,Huang, M.,Jensen, J.K.,Muyldermans, S.,Declerck, P.J.,Komives, E.A.,Andreasen, P.A. Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator. Sci Rep, 7:3385-3385, 2017 Cited by PubMed: 28611361 DOI: 10.1038/s41598-017-03457-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation