5LHB
POLYADPRIBOSYL GLYCOSIDASE IN COMPLEX WITH PDD00017262
Summary for 5LHB
Entry DOI | 10.2210/pdb5lhb/pdb |
Descriptor | Poly(ADP-ribose) glycohydrolase, 1-(cyclopropylmethyl)-6-[[(1-methylcyclopropyl)amino]-bis(oxidanyl)-$l^{4}-sulfanyl]-3-[(2-methyl-1,3-thiazol-5-yl)methyl]quinazoline-2,4-dione, SULFATE ION, ... (5 entities in total) |
Functional Keywords | hydrolase, competitive inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 62081.67 |
Authors | Tucker, J.,Barkauskaite, E. (deposition date: 2016-07-10, release date: 2016-10-12, Last modification date: 2024-01-10) |
Primary citation | James, D.I.,Smith, K.M.,Jordan, A.M.,Fairweather, E.E.,Griffiths, L.A.,Hamilton, N.S.,Hitchin, J.R.,Hutton, C.P.,Jones, S.,Kelly, P.,McGonagle, A.E.,Small, H.,Stowell, A.I.,Tucker, J.,Waddell, I.D.,Waszkowycz, B.,Ogilvie, D.J. First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib. ACS Chem. Biol., 11:3179-3190, 2016 Cited by PubMed: 27689388DOI: 10.1021/acschembio.6b00609 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.23 Å) |
Structure validation
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