5LGS

Crystal structure of mouse CARM1 in complex with ligand P2C3u

5LGS の概要

• エントリーDOI: 10.2210/pdb5lgs/pdb
• 分子名称: Histone-arginine methyltransferase CARM1, Polyadenylate-binding protein 1, SULFATE ION, ... (9 entities in total)
• 機能のキーワード: protein arginine methyltransferase, catalytic domain, chromatin regulator, mrna processing, mrna splicing, nucleus, s-adenosyl-l-methionine, transcription, transcription regulation, transferase
• 由来する生物種: Mus musculus (Mouse); 詳細
• 細胞内の位置: Nucleus: Q9WVG6; Cytoplasm: P11940
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 169124.22

構造登録者

Marechal, N.,Troffer-Charlier, N.,Cura, V.,Bonnefond, L.,Cavarelli, J. (登録日: 2016-07-08, 公開日: 2017-03-22, 最終更新日: 2024-01-10)

• 主引用文献: van Haren, M.J.,Marechal, N.,Troffer-Charlier, N.,Cianciulli, A.,Sbardella, G.,Cavarelli, J.,Martin, N.I.; Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1.; Proc. Natl. Acad. Sci. U.S.A., 114:3625-3630, 2017; PubMed: 28330993; DOI: 10.1073/pnas.1618401114

実験手法

X-RAY DIFFRACTION (2.1 Å)