5LGR

Crystal structure of mouse CARM1 in complex with ligand P1C3u

Summary for 5LGR

Entry DOI	10.2210/pdb5lgr/pdb
Descriptor	Histone-arginine methyltransferase CARM1, ACETYL GROUP, Polyadenylate-binding protein 1, ... (11 entities in total)
Functional Keywords	protein arginine methyltransferase, catalytic domain, chromatin regulator, mrna processing, mrna splicing, nucleus, s-adenosyl-l-methionine, transcription, transcription regulation, transferase
Biological source	Mus musculus (House mouse) More
Cellular location	Nucleus: Q9WVG6 Cytoplasm: P11940
Total number of polymer chains	8
Total formula weight	171080.61
Authors	Marechal, N.,Troffer-Charlier, N.,Cura, V.,Bonnefond, L.,Cavarelli, J. (deposition date: 2016-07-08, release date: 2017-03-22, Last modification date: 2024-01-10)
Primary citation	van Haren, M.J.,Marechal, N.,Troffer-Charlier, N.,Cianciulli, A.,Sbardella, G.,Cavarelli, J.,Martin, N.I. Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1. Proc. Natl. Acad. Sci. U.S.A., 114:3625-3630, 2017 Cited by PubMed: 28330993 DOI: 10.1073/pnas.1618401114 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation