5LGN

Thieno[3,2-b]pyrrole-5-carboxamides as Novel Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1: Compound 19

Summary for 5LGN

Entry DOI	10.2210/pdb5lgn/pdb
Descriptor	Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE, ... (4 entities in total)
Functional Keywords	oxidoreductase
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus : O60341 Q9UKL0
Total number of polymer chains	2
Total formula weight	90988.63
Authors	Mattevi, A.,Ciossani, G. (deposition date: 2016-07-07, release date: 2017-02-22, Last modification date: 2024-01-10)
Primary citation	Sartori, L.,Mercurio, C.,Amigoni, F.,Cappa, A.,Faga, G.,Fattori, R.,Legnaghi, E.,Ciossani, G.,Mattevi, A.,Meroni, G.,Moretti, L.,Cecatiello, V.,Pasqualato, S.,Romussi, A.,Thaler, F.,Trifiro, P.,Villa, M.,Vultaggio, S.,Botrugno, O.A.,Dessanti, P.,Minucci, S.,Zagarri, E.,Carettoni, D.,Iuzzolino, L.,Varasi, M.,Vianello, P. Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration. J. Med. Chem., 60:1673-1692, 2017 Cited by PubMed: 28186755 DOI: 10.1021/acs.jmedchem.6b01018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation