5LFH

NMR structure of peptide 10 targeting CXCR4

Summary for 5LFH

• Entry DOI: 10.2210/pdb5lfh/pdb
• NMR Information: BMRB: 34017
• Descriptor: ACE-ARG-ALA-DCY-ARG-PHE-PHE-CYS (1 entity in total)
• Functional Keywords: cxcr4, cxcl12, cxcr4 antagonists, cancer, molecular invasion, drug design, chemokine, cytokine
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 930.15

Authors

Di Maro, S.,Trotta, A.M.,Brancaccio, D.,Di Leva, F.S.,La Pietra, V.,Ierano, C.,Napolitano, M.,Portella, L.,D'Alterio, C.,Siciliano, R.A.,Sementa, D.,Tomassi, S.,Carotenuto, A.,Novellino, E.,Scala, S.,Marinelli, L. (deposition date: 2016-07-01, release date: 2016-09-07, Last modification date: 2016-10-05)

• Primary citation: Di Maro, S.,Trotta, A.M.,Brancaccio, D.,Di Leva, F.S.,La Pietra, V.,Ierano, C.,Napolitano, M.,Portella, L.,D'Alterio, C.,Siciliano, R.A.,Sementa, D.,Tomassi, S.,Carotenuto, A.,Novellino, E.,Scala, S.,Marinelli, L.; Exploring the N-Terminal Region of C-X-C Motif Chemokine 12 (CXCL12): Identification of Plasma-Stable Cyclic Peptides As Novel, Potent C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonists.; J.Med.Chem., 59:8369-8380, 2016; PubMed: 27571038; DOI: 10.1021/acs.jmedchem.6b00695

Experimental method

SOLUTION NMR