5LCT

Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with a R-methyl-piperazine substituted Fasudil-derivative (Ligand 02)

Summary for 5LCT

• Entry DOI: 10.2210/pdb5lct/pdb
• Related: 5LCP 5LCQ 5LCR
• Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 5-[(2~{R})-2-methylpiperazin-1-yl]sulfonylisoquinoline, ... (6 entities in total)
• Functional Keywords: pka, kinase, fasudil-derivative, inhibition, cocrystal, 3x-phosphorylated, ligand 21, transferase
• Biological source: Cricetulus griseus (Chinese hamster); More
• Cellular location: Cytoplasm : P25321
• Total number of polymer chains: 2
• Total formula weight: 43813.80

Authors

Wienen-Schmidt, B.,Heine, A.,Klebe, G. (deposition date: 2016-06-22, release date: 2018-01-17, Last modification date: 2024-01-10)

• Primary citation: Wienen-Schmidt, B.,Jonker, H.R.A.,Wulsdorf, T.,Gerber, H.-D.,Saxena, K.,Kudlinzki, D.,Sreeramulu, S.,Parigi, G.,Luchinat, C.,Heine, A.,Schwalbe, H.,Klebe, G.; Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with different Fasudil-derivatives; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.615 Å)