5LCT

Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with a R-methyl-piperazine substituted Fasudil-derivative (Ligand 02)

5LCT の概要

• エントリーDOI: 10.2210/pdb5lct/pdb
• 関連するPDBエントリー: 5LCP 5LCQ 5LCR
• 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 5-[(2~{R})-2-methylpiperazin-1-yl]sulfonylisoquinoline, ... (6 entities in total)
• 機能のキーワード: pka, kinase, fasudil-derivative, inhibition, cocrystal, 3x-phosphorylated, ligand 21, transferase
• 由来する生物種: Cricetulus griseus (Chinese hamster); 詳細
• 細胞内の位置: Cytoplasm : P25321
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43813.80

構造登録者

Wienen-Schmidt, B.,Heine, A.,Klebe, G. (登録日: 2016-06-22, 公開日: 2018-01-17, 最終更新日: 2024-01-10)

• 主引用文献: Wienen-Schmidt, B.,Jonker, H.R.A.,Wulsdorf, T.,Gerber, H.-D.,Saxena, K.,Kudlinzki, D.,Sreeramulu, S.,Parigi, G.,Luchinat, C.,Heine, A.,Schwalbe, H.,Klebe, G.; Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with different Fasudil-derivatives; To Be Published,

実験手法

X-RAY DIFFRACTION (1.615 Å)