5LCQ
Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with long-chain Fasudil-derivative (Ligand 05)
Summary for 5LCQ
Entry DOI | 10.2210/pdb5lcq/pdb |
Related | 5LCP |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, ~{N}-[2-(propylamino)ethyl]isoquinoline-5-sulfonamide, ... (6 entities in total) |
Functional Keywords | pka, kinase, fasudil-derivative, inhibition, cocrystal, 3x-phosphorylated, ligand 08, transferase |
Biological source | Cricetulus griseus (Chinese hamster) More |
Cellular location | Cytoplasm : P25321 |
Total number of polymer chains | 2 |
Total formula weight | 43815.82 |
Authors | Wienen-Schmidt, B.,Heine, A.,Klebe, G. (deposition date: 2016-06-22, release date: 2018-01-17, Last modification date: 2024-01-10) |
Primary citation | Wienen, B.,Jonker, H.R.A.,Wulsdorf, T.,Gerber, H.-D.,Saxena, K.,Kudlinzki, D.,Sreeramulu, S.,Parigi, G.,Luchinat, C.,Heine, A.,Schwalbe, H.,Klebe, G. Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with different Fasudil-derivatives To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.423 Å) |
Structure validation
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