5LC0

Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor

Summary for 5LC0

Entry DOI	10.2210/pdb5lc0/pdb
Descriptor	NS2B-NS3 protease,NS2B-NS3 protease, N-((S)-3-(4-(aminomethyl)phenyl)-1-(((R)-4-guanidino-1-(5-hydroxy-1,3,2-dioxaborinan-2-yl)butyl)amino)-1-oxopropan-2-yl)benzamide (3 entities in total)
Functional Keywords	zika virus ns2b-ns3 protease, antiviral agents, boronic-acid inhibitor, cyclic diester with glycerol, hydrolase
Biological source	Zika virus (ZIKV) More
Cellular location	Virion membrane ; Multi-pass membrane protein : A0A140DLX4
Total number of polymer chains	2
Total formula weight	49487.00
Authors	Lei, J.,Hansen, G.,Zhang, L.L.,Hilgenfeld, R. (deposition date: 2016-06-18, release date: 2016-07-06, Last modification date: 2024-01-10)
Primary citation	Lei, J.,Hansen, G.,Nitsche, C.,Klein, C.D.,Zhang, L.,Hilgenfeld, R. Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor. Science, 353:503-505, 2016 Cited by PubMed: 27386922 DOI: 10.1126/science.aag2419 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation