5LBZ
Structure of the human quinone reductase 2 (NQO2) in complex with pacritinib
Summary for 5LBZ
Entry DOI | 10.2210/pdb5lbz/pdb |
Descriptor | Ribosyldihydronicotinamide dehydrogenase [quinone], FLAVIN-ADENINE DINUCLEOTIDE, 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene, ... (6 entities in total) |
Functional Keywords | quinone reductase 2, kinase inhibitor, pancritinib, ribosyldihydronicotinamide dehydrogenase (nqo2), oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P16083 |
Total number of polymer chains | 2 |
Total formula weight | 56582.12 |
Authors | Schneider, S.,Medard, G.,Kuster, B. (deposition date: 2016-06-17, release date: 2017-11-29, Last modification date: 2024-01-10) |
Primary citation | Klaeger, S.,Heinzlmeir, S.,Wilhelm, M.,Polzer, H.,Vick, B.,Koenig, P.A.,Reinecke, M.,Ruprecht, B.,Petzoldt, S.,Meng, C.,Zecha, J.,Reiter, K.,Qiao, H.,Helm, D.,Koch, H.,Schoof, M.,Canevari, G.,Casale, E.,Depaolini, S.R.,Feuchtinger, A.,Wu, Z.,Schmidt, T.,Rueckert, L.,Becker, W.,Huenges, J.,Garz, A.K.,Gohlke, B.O.,Zolg, D.P.,Kayser, G.,Vooder, T.,Preissner, R.,Hahne, H.,Tonisson, N.,Kramer, K.,Gotze, K.,Bassermann, F.,Schlegl, J.,Ehrlich, H.C.,Aiche, S.,Walch, A.,Greif, P.A.,Schneider, S.,Felder, E.R.,Ruland, J.,Medard, G.,Jeremias, I.,Spiekermann, K.,Kuster, B. The target landscape of clinical kinase drugs. Science, 358:-, 2017 Cited by PubMed: 29191878DOI: 10.1126/science.aan4368 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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