5LAV

Novel Spiro[3H-indole-3,2 -pyrrolidin]-2(1H)-one Inhibitors of the MDM2-p53 Interaction: HDM2 (MDM2) in complex with compound 6b

Summary for 5LAV

• Entry DOI: 10.2210/pdb5lav/pdb
• Descriptor: E3 ubiquitin-protein ligase Mdm2, (3~{S},3'~{S},4'~{S})-4'-azanyl-6-chloranyl-3'-(3-chlorophenyl)-1'-(2,2-dimethylpropyl)spiro[1~{H}-indole-3,2'-pyrrolidine]-2-one, SULFATE ION, ... (4 entities in total)
• Functional Keywords: vienna, ppi, mdm2, hdm2, bi, ligase
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus, nucleoplasm: Q00987
• Total number of polymer chains: 1
• Total formula weight: 11398.22

Authors

Kessler, D.,Gollner, A. (deposition date: 2016-06-15, release date: 2016-11-02, Last modification date: 2018-04-25)

• Primary citation: Gollner, A.,Rudolph, D.,Arnhof, H.,Bauer, M.,Blake, S.M.,Boehmelt, G.,Cockroft, X.L.,Dahmann, G.,Ettmayer, P.,Gerstberger, T.,Karolyi-Oezguer, J.,Kessler, D.,Kofink, C.,Ramharter, J.,Rinnenthal, J.,Savchenko, A.,Schnitzer, R.,Weinstabl, H.,Weyer-Czernilofsky, U.,Wunberg, T.,McConnell, D.B.; Discovery of Novel Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2-p53 Interaction.; J. Med. Chem., 59:10147-10162, 2016; PubMed: 27775892; DOI: 10.1021/acs.jmedchem.6b00900

Experimental method

X-RAY DIFFRACTION (1.73 Å)