5LAP
p53 cancer mutant Y220C with Cys182 alkylation
Summary for 5LAP
| Entry DOI | 10.2210/pdb5lap/pdb |
| Descriptor | Cellular tumor antigen p53, ZINC ION, 5-chloranylpyrimidine-4-carboxylic acid, ... (4 entities in total) |
| Functional Keywords | p53, tumor suppressor, cancer mutation, protein stabilization, alkylating agents, 2-sulfonylpyrimidines, cancer therapy, dna binding protein |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
| Total number of polymer chains | 2 |
| Total formula weight | 49509.53 |
| Authors | Joerger, A.C.,Bauer, M.R.,Fersht, A.R. (deposition date: 2016-06-14, release date: 2016-08-10, Last modification date: 2024-01-10) |
| Primary citation | Bauer, M.R.,Joerger, A.C.,Fersht, A.R. 2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells. Proc.Natl.Acad.Sci.USA, 113:E5271-E5280, 2016 Cited by PubMed: 27551077DOI: 10.1073/pnas.1610421113 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.42 Å) |
Structure validation
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