5LAP
p53 cancer mutant Y220C with Cys182 alkylation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cellular tumor antigen p53 | polymer | 219 | 24530.8 | 2 | UniProt (P04637) Pfam (PF00870) | Homo sapiens (Human) | Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53 |
| 2 | C, E (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, F (A, B) | 5-chloranylpyrimidine-4-carboxylic acid | non-polymer | 158.5 | 2 | Chemie (6SM) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 541 | Chemie (HOH) |
Sequence modifications
A, B: 94 - 312 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| Leu 133 | Met 133 | engineered mutation |
| Ala 203 | Val 203 | engineered mutation |
| Cys 220 | Tyr 220 | engineered mutation |
| Tyr 239 | Asn 239 | engineered mutation |
| Asp 268 | Asn 268 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 49061.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 447.9 | |
| All* | Total formula weight | 49509.5 |
