5L9B

HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) IN COMPLEX WITH 2-OXOGLUTARATE (2OG) AND HIF-1ALPHA CODD (556-574)

5L9B の概要

• エントリーDOI: 10.2210/pdb5l9b/pdb
• 関連するPDBエントリー: 3HQR 4BQY 5L9R
• 分子名称: Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ... (5 entities in total)
• 機能のキーワード: oxidoreductase, non-heme dioxygenase, iron, 2-oxoglutarate, hypoxia-inducible factor, hif, hif prolyl hydroxylase domain 2, phd2, egln1, oxygenase, hypoxia, dna-binding, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, cytoplasm, transcription/epigenetic regulation, signaling, development, cell structure, beta-hydroxylation, transcription activator/inhibitor, ubl conjugation, polymorphism, vitamin c, zinc-finger, familial erythrocytosis, breast cancer, transcription complex
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cytoplasm : Q9GZT9 Q16665
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 60868.66

構造登録者

Chowdhury, R.,Schofield, C.J. (登録日: 2016-06-10, 公開日: 2016-08-31, 最終更新日: 2024-01-10)

• 主引用文献: Chowdhury, R.,Leung, I.K.,Tian, Y.M.,Abboud, M.I.,Ge, W.,Domene, C.,Cantrelle, F.X.,Landrieu, I.,Hardy, A.P.,Pugh, C.W.,Ratcliffe, P.J.,Claridge, T.D.,Schofield, C.J.; Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.; Nat Commun, 7:12673-12673, 2016; PubMed: 27561929; DOI: 10.1038/ncomms12673

実験手法

X-RAY DIFFRACTION (1.95 Å)