5L9B
HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) IN COMPLEX WITH 2-OXOGLUTARATE (2OG) AND HIF-1ALPHA CODD (556-574)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0031418 | molecular_function | L-ascorbic acid binding |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| B | 0031418 | molecular_function | L-ascorbic acid binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 501 |
| Chain | Residue |
| A | HIS313 |
| A | ASP315 |
| A | HIS374 |
| A | AKG502 |
| A | HOH647 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue AKG A 502 |
| Chain | Residue |
| A | ASP315 |
| A | ILE327 |
| A | TYR329 |
| A | HIS374 |
| A | VAL376 |
| A | ARG383 |
| A | MN501 |
| A | HOH607 |
| A | HOH613 |
| A | HOH647 |
| C | PRO564 |
| A | ARG252 |
| A | MET299 |
| A | TYR310 |
| A | HIS313 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MN B 501 |
| Chain | Residue |
| B | HIS313 |
| B | ASP315 |
| B | HIS374 |
| B | AKG502 |
| B | HOH618 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for residue AKG B 502 |
| Chain | Residue |
| B | MET299 |
| B | TYR310 |
| B | HIS313 |
| B | ASP315 |
| B | TYR329 |
| B | HIS374 |
| B | VAL376 |
| B | ARG383 |
| B | MN501 |
| B | HOH639 |
| B | HOH648 |
| B | HOH660 |
| D | PRO564 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 202 |
| Details | Domain: {"description":"Fe2OG dioxygenase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00805","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Region: {"description":"Beta(2)beta(3) 'finger-like' loop","evidences":[{"source":"PubMed","id":"18063574","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16782814","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19604478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28594552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2G19","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HQU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V18","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19604478","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"21601578","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"4-hydroxyproline","evidences":[{"source":"PubMed","id":"11292861","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11566883","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12351678","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25974097","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
