5L87
Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat trypanosomiases.
Summary for 5L87
Entry DOI | 10.2210/pdb5l87/pdb |
Related | 2W84 |
Descriptor | Peroxin 14, 5-(1~{H}-indol-3-ylmethyl)-1-methyl-~{N}-(naphthalen-1-ylmethyl)-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | trypanosomiasis, glycosome, protein-protein interaction inhibitor, structure-based drug discovery, inhibitor, membrane protein |
Biological source | Trypanosoma brucei brucei |
Total number of polymer chains | 1 |
Total formula weight | 8394.69 |
Authors | Dawidowski, M.,Emmanouilidis, L.,Sattler, M.,Popowicz, G.M. (deposition date: 2016-06-07, release date: 2017-03-08, Last modification date: 2024-01-10) |
Primary citation | Dawidowski, M.,Emmanouilidis, L.,Kalel, V.C.,Tripsianes, K.,Schorpp, K.,Hadian, K.,Kaiser, M.,Maser, P.,Kolonko, M.,Tanghe, S.,Rodriguez, A.,Schliebs, W.,Erdmann, R.,Sattler, M.,Popowicz, G.M. Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites. Science, 355:1416-1420, 2017 Cited by PubMed: 28360328DOI: 10.1126/science.aal1807 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (0.87 Å) |
Structure validation
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