5L87

Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat trypanosomiases.

5L87 の概要

関連するPDBエントリー2W84
分子名称Peroxin 14, 5-(1~{H}-indol-3-ylmethyl)-1-methyl-~{N}-(naphthalen-1-ylmethyl)-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
機能のキーワードtrypanosomiasis, glycosome, protein-protein interaction inhibitor, structure-based drug discovery, inhibitor, membrane protein
由来する生物種Trypanosoma brucei brucei
ポリマー鎖数1
分子量合計8394.69
構造登録者
Dawidowski, M.,Emmanouilidis, L.,Sattler, M.,Popowicz, G.M. (登録日: 2016-06-07, 公開日: 2017-03-08, 最終更新日: 2017-04-12)
主引用文献
Dawidowski, M.,Emmanouilidis, L.,Kalel, V.C.,Tripsianes, K.,Schorpp, K.,Hadian, K.,Kaiser, M.,Maser, P.,Kolonko, M.,Tanghe, S.,Rodriguez, A.,Schliebs, W.,Erdmann, R.,Sattler, M.,Popowicz, G.M.
Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites.
Science, 355:1416-1420, 2017
PubMed: 28360328 (主引用文献が同じPDBエントリー)
DOI: 10.1126/science.aal1807
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (0.87 Å)
?

構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.1454000MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード

他の静止画像(非対称単位)

Molmil generated image of 5l87
回転なし
Molmil generated image of 5l87
x軸(左右方向)周りに90°回転
Molmil generated image of 5l87
y軸(上下方向)周りに90°回転