5L4F

Crystal Structure of Human Transthyretin in Complex with 2,6-Dinitro-p-cresol (DNPC)

Summary for 5L4F

Entry DOI	10.2210/pdb5l4f/pdb
Related	1F41
Descriptor	Transthyretin, 2,6-Dinitro-p-cresol, SODIUM ION, ... (4 entities in total)
Functional Keywords	transport protein, thyroxine binding, 2, 6-dinitro-p-cresol (dnpc)complex
Biological source	Homo sapiens (Human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	27973.98
Authors	Grundstrom, C.,Hall, M.,Zhang, J.,Olofsson, A.,Andersson, P.,Sauer-Eriksson, A.E. (deposition date: 2016-05-25, release date: 2016-10-05, Last modification date: 2024-01-10)
Primary citation	Zhang, J.,Begum, A.,Brannstrom, K.,Grundstrom, C.,Iakovleva, I.,Olofsson, A.,Sauer-Eriksson, A.E.,Andersson, P.L. Structure-Based Virtual Screening Protocol for in Silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin. Environ. Sci. Technol., 50:11984-11993, 2016 Cited by PubMed: 27668830 DOI: 10.1021/acs.est.6b02771 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.48 Å)

Structure validation