Crystal Structure of Human Carbonic Anhydrase II in Complex with a Quinoline Oligoamide Foldamer

Summary for 5L3O

DescriptorCarbonic anhydrase 2, ZINC ION, ~{N}-[[3-(4-formamidobutoxy)phenyl]methyl]-4-sulfamoyl-benzamide, ... (9 entities in total)
Functional Keywordsprotein-foldamer complex, protein foldamer interactions, modified inhibitor, anchored foldamer, hcaii dimerisation, quinoline oligoamide foldamer, benzene sulfonamide modified inhibitor, lyase-inhibitor complex, lyase/inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight64927.33
Jewginski, M.,Langlois d'Estaintot, B.,Granier, T.,Huc, Y. (deposition date: 2016-05-24, release date: 2017-03-01, Last modification date: 2019-08-21)
Primary citation
Jewginski, M.,Granier, T.,Langlois d'Estaintot, B.,Fischer, L.,Mackereth, C.D.,Huc, I.
Self-Assembled Protein-Aromatic Foldamer Complexes with 2:3 and 2:2:1 Stoichiometries.
J. Am. Chem. Soc., 139:2928-2931, 2017
PubMed: 28170240 (PDB entries with the same primary citation)
DOI: 10.1021/jacs.7b00184
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24920 0.2% 0.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-11-25