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5L3C

Human LSD1/CoREST: LSD1 E379K mutation

Summary for 5L3C
Entry DOI10.2210/pdb5l3c/pdb
DescriptorLysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE (3 entities in total)
Functional Keywordsoxidoreductase-repressor complex, histone demethylase, chromatin, flavin, fad, oxidoreductase/repressor
Biological sourceHomo sapiens (Human)
More
Cellular locationNucleus : O60341 Q9UKL0
Total number of polymer chains2
Total formula weight146899.03
Authors
Pilotto, S.,Speranzini, V.,Marabelli, C.,Mattevi, A. (deposition date: 2016-04-06, release date: 2016-05-04, Last modification date: 2024-01-10)
Primary citationPilotto, S.,Speranzini, V.,Marabelli, C.,Rusconi, F.,Toffolo, E.,Grillo, B.,Battaglioli, E.,Mattevi, A.
LSD1/KDM1A mutations associated to a newly described form of intellectual disability impair demethylase activity and binding to transcription factors.
Hum.Mol.Genet., 25:2578-2587, 2016
Cited by
PubMed: 27094131
DOI: 10.1093/hmg/ddw120
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.31 Å)
Structure validation

217705

數據於2024-03-27公開中

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