5L04

STRUCTURE OF INTERFERON LAMBDA 1 RECEPTOR WITH HUMAN KINASE JAK1

Summary for 5L04

Entry DOI	10.2210/pdb5l04/pdb
Descriptor	Tyrosine-protein kinase JAK1, Interferon lambda receptor 1 (3 entities in total)
Functional Keywords	complex of jak1 and interferon lambda 1, jak kinase, intracellular domain of ifnlr1, ferm domain, sh2-like domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human) More
Cellular location	Endomembrane system; Peripheral membrane protein: P23458 Membrane ; Single-pass type I membrane protein : Q8IU57
Total number of polymer chains	2
Total formula weight	69430.31
Authors	Lubkowski, J.,Wlodawer, A.,Zhang, D. (deposition date: 2016-07-26, release date: 2016-10-12, Last modification date: 2024-03-06)
Primary citation	Zhang, D.,Wlodawer, A.,Lubkowski, J. Crystal Structure of a Complex of the Intracellular Domain of Interferon lambda Receptor 1 (IFNLR1) and the FERM/SH2 Domains of Human JAK1. J. Mol. Biol., 428:4651-4668, 2016 Cited by PubMed: 27725180 DOI: 10.1016/j.jmb.2016.10.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation