5KZI

Crystal structure of human Pim-1 kinase in complex with an imidazopyridazine inhibitor.

Summary for 5KZI

Entry DOI	10.2210/pdb5kzi/pdb
Descriptor	Serine/threonine-protein kinase pim-1, ~{N}-[4-[(3~{S})-3-azanylpiperidin-1-yl]pyridin-3-yl]-2-[2,6-bis(fluoranyl)phenyl]imidazo[1,5-b]pyridazin-7-amine (3 entities in total)
Functional Keywords	transferase, serine/threonine protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	33485.87
Authors	Mohr, C. (deposition date: 2016-07-25, release date: 2016-11-09, Last modification date: 2024-03-06)
Primary citation	Wurz, R.P.,Sastri, C.,D'Amico, D.C.,Herberich, B.,Jackson, C.L.,Pettus, L.H.,Tasker, A.S.,Wu, B.,Guerrero, N.,Lipford, J.R.,Winston, J.T.,Yang, Y.,Wang, P.,Nguyen, Y.,Andrews, K.L.,Huang, X.,Lee, M.R.,Mohr, C.,Zhang, J.D.,Reid, D.L.,Xu, Y.,Zhou, Y.,Wang, H.L. Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors. Bioorg. Med. Chem. Lett., 26:5580-5590, 2016 Cited by PubMed: 27769621 DOI: 10.1016/j.bmcl.2016.09.067 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation