5KX8
Irak4-inhibitor co-structure
Summary for 5KX8
Entry DOI | 10.2210/pdb5kx8/pdb |
Related | 5KX7 |
Descriptor | Interleukin-1 receptor-associated kinase 4, ~{N}-(3-aminocarbonyl-1-methyl-pyrazol-4-yl)-5-piperazin-1-yl-pyrazolo[1,5-a]pyrimidine-3-carboxamide (3 entities in total) |
Functional Keywords | kinase, phosphatase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q9NWZ3 |
Total number of polymer chains | 4 |
Total formula weight | 137302.30 |
Authors | Fischmann, T.O. (deposition date: 2016-07-20, release date: 2016-08-17, Last modification date: 2016-08-24) |
Primary citation | Hanisak, J.,Seganish, W.M.,McElroy, W.T.,Tang, H.,Zhang, R.,Tsui, H.C.,Fischmann, T.,Tulshian, D.,Tata, J.,Sondey, C.,Devito, K.,Fossetta, J.,Garlisi, C.G.,Lundell, D.,Niu, X. Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors. Bioorg.Med.Chem.Lett., 26:4250-4255, 2016 Cited by PubMed: 27476420DOI: 10.1016/j.bmcl.2016.07.048 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.671 Å) |
Structure validation
Download full validation report