5KX5

Crystal structure of tubulin-stathmin-TTL-Compound 11 complex

Summary for 5KX5

• Entry DOI: 10.2210/pdb5kx5/pdb
• Descriptor: Tubulin alpha chain, ADENOSINE-5'-DIPHOSPHATE, Tubulin beta chain, ... (11 entities in total)
• Functional Keywords: tubulin tubulysin, structural protein-inhibitor complex, structural protein/inhibitor
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Cytoplasm, cytoskeleton : D0VWZ0 D0VWY9; Golgi apparatus : P63043
• Total number of polymer chains: 6
• Total formula weight: 265698.15

Authors

Parris, K. (deposition date: 2016-07-20, release date: 2016-12-28, Last modification date: 2023-10-04)

• Primary citation: Leverett, C.A.,Sukuru, S.C.,Vetelino, B.C.,Musto, S.,Parris, K.,Pandit, J.,Loganzo, F.,Varghese, A.H.,Bai, G.,Liu, B.,Liu, D.,Hudson, S.,Doppalapudi, V.R.,Stock, J.,O'Donnell, C.J.,Subramanyam, C.; Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads.; ACS Med Chem Lett, 7:999-1004, 2016; PubMed: 27882198; DOI: 10.1021/acsmedchemlett.6b00274

Experimental method

X-RAY DIFFRACTION (2.5 Å)