5KX5
Crystal structure of tubulin-stathmin-TTL-Compound 11 complex
Summary for 5KX5
Entry DOI | 10.2210/pdb5kx5/pdb |
Descriptor | Tubulin alpha chain, ADENOSINE-5'-DIPHOSPHATE, Tubulin beta chain, ... (11 entities in total) |
Functional Keywords | tubulin tubulysin, structural protein-inhibitor complex, structural protein/inhibitor |
Biological source | Rattus norvegicus (Rat) More |
Cellular location | Cytoplasm, cytoskeleton : D0VWZ0 D0VWY9 Golgi apparatus : P63043 |
Total number of polymer chains | 6 |
Total formula weight | 265698.15 |
Authors | Parris, K. (deposition date: 2016-07-20, release date: 2016-12-28, Last modification date: 2023-10-04) |
Primary citation | Leverett, C.A.,Sukuru, S.C.,Vetelino, B.C.,Musto, S.,Parris, K.,Pandit, J.,Loganzo, F.,Varghese, A.H.,Bai, G.,Liu, B.,Liu, D.,Hudson, S.,Doppalapudi, V.R.,Stock, J.,O'Donnell, C.J.,Subramanyam, C. Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads. ACS Med Chem Lett, 7:999-1004, 2016 Cited by PubMed: 27882198DOI: 10.1021/acsmedchemlett.6b00274 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report