5KX5

Crystal structure of tubulin-stathmin-TTL-Compound 11 complex

5KX5 の概要

• エントリーDOI: 10.2210/pdb5kx5/pdb
• 分子名称: Tubulin alpha chain, ADENOSINE-5'-DIPHOSPHATE, Tubulin beta chain, ... (11 entities in total)
• 機能のキーワード: tubulin tubulysin, structural protein-inhibitor complex, structural protein/inhibitor
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• 細胞内の位置: Cytoplasm, cytoskeleton : D0VWZ0 D0VWY9; Golgi apparatus : P63043
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 265698.15

構造登録者

Parris, K. (登録日: 2016-07-20, 公開日: 2016-12-28, 最終更新日: 2023-10-04)

• 主引用文献: Leverett, C.A.,Sukuru, S.C.,Vetelino, B.C.,Musto, S.,Parris, K.,Pandit, J.,Loganzo, F.,Varghese, A.H.,Bai, G.,Liu, B.,Liu, D.,Hudson, S.,Doppalapudi, V.R.,Stock, J.,O'Donnell, C.J.,Subramanyam, C.; Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads.; ACS Med Chem Lett, 7:999-1004, 2016; PubMed: 27882198; DOI: 10.1021/acsmedchemlett.6b00274

実験手法

X-RAY DIFFRACTION (2.5 Å)