5KVT

THE STRUCTURE OF TRKA KINASE DOMAIN BOUND TO THE INHIBITOR ENTRECTINIB

5KVT の概要

• エントリーDOI: 10.2210/pdb5kvt/pdb
• 分子名称: High affinity nerve growth factor receptor, Entrectinib, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: kinase, transferase-transferase inhibitor complex, transferase-transfer complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane ; Single- pass type I membrane protein : P04629
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34161.39

構造登録者

Jin, L.,Yan, S.,Wei, G.,Li, G.,Harris, J.,Vernier, J.-M. (登録日: 2016-07-15, 公開日: 2017-12-27, 最終更新日: 2023-10-04)

• 主引用文献: Drilon, A.; Antitumor Activity and Safety of the Pan-TRK, ROS1, and ALK inhibitor Entrectinib (RXDX-101): Combined Results from Two Phase I Trials; To Be Published,

実験手法

X-RAY DIFFRACTION (2.45 Å)