5KUP
Bruton's tyrosine kinase (BTK) with pyridazinone compound 9
Summary for 5KUP
Entry DOI | 10.2210/pdb5kup/pdb |
Descriptor | Tyrosine-protein kinase BTK, SULFATE ION, GLYCEROL, ... (6 entities in total) |
Functional Keywords | protein kinase, inhibitor, non covalent, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q06187 |
Total number of polymer chains | 1 |
Total formula weight | 32812.60 |
Authors | Eigenbrot, C.,Yu, C. (deposition date: 2016-07-13, release date: 2016-09-14, Last modification date: 2023-10-04) |
Primary citation | Johnson, A.R.,Kohli, P.B.,Katewa, A.,Gogol, E.,Belmont, L.D.,Choy, R.,Penuel, E.,Burton, L.,Eigenbrot, C.,Yu, C.,Ortwine, D.F.,Bowman, K.,Franke, Y.,Tam, C.,Estevez, A.,Mortara, K.,Wu, J.,Li, H.,Lin, M.,Bergeron, P.,Crawford, J.J.,Young, W.B. Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations. Acs Chem.Biol., 11:2897-2907, 2016 Cited by PubMed: 27571029DOI: 10.1021/acschembio.6b00480 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.389 Å) |
Structure validation
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