5KSH
Crystal structure of penicillin-binding protein 2 from Neisseria gonorrhoeae containing an A501T mutation associated with cephalosporin resistance
Summary for 5KSH
Entry DOI | 10.2210/pdb5ksh/pdb |
Descriptor | Penicillin-binding protein 2, GLYCEROL, SULFATE ION, ... (4 entities in total) |
Functional Keywords | biosynthetic protein, class b transpeptidase, peptidoglycan synthesis |
Biological source | Neisseria gonorrhoeae |
Total number of polymer chains | 2 |
Total formula weight | 119478.78 |
Authors | Fedarovich, A.,Davies, C. (deposition date: 2016-07-08, release date: 2017-03-01, Last modification date: 2023-10-04) |
Primary citation | Tomberg, J.,Fedarovich, A.,Vincent, L.R.,Jerse, A.E.,Unemo, M.,Davies, C.,Nicholas, R.A. Alanine 501 Mutations in Penicillin-Binding Protein 2 from Neisseria gonorrhoeae: Structure, Mechanism, and Effects on Cephalosporin Resistance and Biological Fitness. Biochemistry, 56:1140-1150, 2017 Cited by PubMed: 28145684DOI: 10.1021/acs.biochem.6b01030 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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