5KRS

HIV-1 Integrase Catalytic Core Domain in Complex with an Allosteric Inhibitor, 3-(1H-pyrrol-1-yl)-2-thiophenecarboxylic acid

5KRS の概要

• エントリーDOI: 10.2210/pdb5krs/pdb
• 関連するPDBエントリー: 5KRB
• 分子名称: Integrase, DIMETHYL SULFOXIDE, 3-pyrrol-1-ylthiophene-2-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: hiv-1 integrase catalytic core domain, p75/ledgf inhibitor, hydrolase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17446.62

構造登録者

Patel, D.,Bauman, J.D.,Arnold, E. (登録日: 2016-07-07, 公開日: 2016-09-28, 最終更新日: 2022-03-23)

• 主引用文献: Patel, D.,Antwi, J.,Koneru, P.C.,Serrao, E.,Forli, S.,Kessl, J.J.,Feng, L.,Deng, N.,Levy, R.M.,Fuchs, J.R.,Olson, A.J.,Engelman, A.N.,Bauman, J.D.,Kvaratskhelia, M.,Arnold, E.; A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain.; J.Biol.Chem., 291:23569-23577, 2016; PubMed: 27645997; DOI: 10.1074/jbc.M116.753384

実験手法

X-RAY DIFFRACTION (1.7 Å)