5KRE

Covalent inhibitor of LYPLAL1

5KRE の概要

• エントリーDOI: 10.2210/pdb5kre/pdb
• 分子名称: Lysophospholipase-like protein 1, (2~{R})-2-phenylpiperidine-1-carbaldehyde, NITRATE ION, ... (4 entities in total)
• 機能のキーワード: lyplal1, serine hydrolase, covalent inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Isoform 1: Cytoplasm, cytosol . Isoform 2: Cytoplasm, cytosol : Q5VWZ2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26772.90

構造登録者

Pandit, J. (登録日: 2016-07-07, 公開日: 2016-07-20, 最終更新日: 2023-10-04)

• 主引用文献: Ahn, K.,Boehm, M.,Brown, M.F.,Calloway, J.,Che, Y.,Chen, J.,Fennell, K.F.,Geoghegan, K.F.,Gilbert, A.M.,Gutierrez, J.A.,Kalgutkar, A.S.,Lanba, A.,Limberakis, C.,Magee, T.V.,O'Doherty, I.,Oliver, R.,Pabst, B.,Pandit, J.,Parris, K.,Pfefferkorn, J.A.,Rolph, T.P.,Patel, R.,Schuff, B.,Shanmugasundaram, V.,Starr, J.T.,Varghese, A.H.,Vera, N.B.,Vernochet, C.,Yan, J.; Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism.; Acs Chem.Biol., 11:2529-2540, 2016; PubMed: 27391855; DOI: 10.1021/acschembio.6b00266

実験手法

X-RAY DIFFRACTION (2 Å)