5KR2

Protease PR5-SQV

Summary for 5KR2

Entry DOI	10.2210/pdb5kr2/pdb
Related	5KQX 5KQY 5KQZ 5KR0 5KR1
Related PRD ID	PRD_000454
Descriptor	Protease PR5-SQV, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide (3 entities in total)
Functional Keywords	hiv-1 protease, e35d, salt-bridge interaction, natural polymorphism, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	4
Total formula weight	44072.23
Authors	Liu, Z.,Poole, K.M.,Mahon, B.P.,McKenna, R.,Fanucci, G.E. (deposition date: 2016-07-06, release date: 2016-09-21, Last modification date: 2024-03-06)
Primary citation	Liu, Z.,Huang, X.,Hu, L.,Pham, L.,Poole, K.M.,Tang, Y.,Mahon, B.P.,Tang, W.,Li, K.,Goldfarb, N.E.,Dunn, B.M.,McKenna, R.,Fanucci, G.E. Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution. J.Biol.Chem., 291:22741-22756, 2016 Cited by PubMed: 27576689 DOI: 10.1074/jbc.M116.747568 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.78 Å)

Structure validation