5KQX

Protease E35D-SQV

Summary for 5KQX

• Entry DOI: 10.2210/pdb5kqx/pdb
• Related: 5KQY 5KQZ 5KR0 5KR1 5KR2
• Related PRD ID: PRD_000454
• Descriptor: Protease E35D-SQV, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide (3 entities in total)
• Functional Keywords: hiv-1 protease, e35d, salt-bridge interaction, natural polymorphism, hydrolase-hudrolase inhibitor complex, hydrolase/hudrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 22122.17

Authors

Liu, Z.,Poole, K.M.,Mahon, B.P.,McKenna, R.,Fanucci, G.E. (deposition date: 2016-07-06, release date: 2016-09-21, Last modification date: 2024-03-06)

• Primary citation: Liu, Z.,Huang, X.,Hu, L.,Pham, L.,Poole, K.M.,Tang, Y.,Mahon, B.P.,Tang, W.,Li, K.,Goldfarb, N.E.,Dunn, B.M.,McKenna, R.,Fanucci, G.E.; Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution.; J.Biol.Chem., 291:22741-22756, 2016; PubMed: 27576689; DOI: 10.1074/jbc.M116.747568

Experimental method

X-RAY DIFFRACTION (2.4 Å)