5KPO

Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor

Summary for 5KPO

• Entry DOI: 10.2210/pdb5kpo/pdb
• Related: 5KPN 5KPP 5KPQ
• Descriptor: Poly [ADP-ribose] polymerase 1, 1-[[3-(4-ethyl-3-oxidanylidene-piperazin-1-yl)carbonyl-4-fluoranyl-phenyl]methyl]quinazoline-2,4-dione (2 entities in total)
• Functional Keywords: inhibitor, complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: P09874
• Total number of polymer chains: 2
• Total formula weight: 79725.15

Authors

Cao, R.,Wang, Y.L.,Zhou, J.,Yao, H.P.,Huang, N.,Xu, B.L. (deposition date: 2016-07-05, release date: 2016-12-21, Last modification date: 2024-03-20)

• Primary citation: Cao, R.,Wang, Y.L.,Zhou, J.,Yao, H.P.,Huang, N.,Xu, B.L.; Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.65 Å)