5KOS
Discovery of TAK-272: A Novel, Potent and Orally Active Renin In-hibitor
Summary for 5KOS
Entry DOI | 10.2210/pdb5kos/pdb |
Related | 5KOQ 5KOT |
Descriptor | Renin, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-~{tert}-butyl-4-(3-methoxypropylamino)-~{N}-(2-methylpropyl)-~{N}-[(3~{S},5~{R})-5-morpholin-4-ylcarbonylpiperidin-3-yl]pyrimidine-5-carboxamide, ... (6 entities in total) |
Functional Keywords | protein-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted: P00797 |
Total number of polymer chains | 2 |
Total formula weight | 76458.68 |
Authors | Snell, G.P.,Behnke, C.A.,Okada, K.,Hideyuki, O.,Sang, B.-C.,Lane, W. (deposition date: 2016-07-01, release date: 2016-11-16, Last modification date: 2020-07-29) |
Primary citation | Imaeda, Y.,Tokuhara, H.,Fukase, Y.,Kanagawa, R.,Kajimoto, Y.,Kusumoto, K.,Kondo, M.,Snell, G.,Behnke, C.A.,Kuroita, T. Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor. Acs Med.Chem.Lett., 7:933-938, 2016 Cited by PubMed: 27774132DOI: 10.1021/acsmedchemlett.6b00251 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.41 Å) |
Structure validation
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