5KOK

Pavine N-methyltransferase in complex with Tetrahydropapaverine and S-adenosylhomocysteine pH 7.25

5KOK の概要

• エントリーDOI: 10.2210/pdb5kok/pdb
• 関連するPDBエントリー: 5KN4 5KOC 5KPC 5KPG
• 分子名称: Pavine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, (1~{S})-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline, ... (5 entities in total)
• 機能のキーワード: benzylisoquinoline alkaloid biosynthesis, transferase
• 由来する生物種: Thalictrum flavum subsp. glaucum (Yellow meadow rue)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 95016.43

構造登録者

Torres, M.A.,Hoffarth, E.,Eugenio, L.,Savtchouk, J.,Chen, X.,Morris, J.,Facchini, P.J.,Ng, K.K.S. (登録日: 2016-06-30, 公開日: 2016-09-07, 最終更新日: 2023-10-04)

• 主引用文献: Torres, M.A.,Hoffarth, E.,Eugenio, L.,Savtchouk, J.,Chen, X.,Morris, J.S.,Facchini, P.J.,Ng, K.K.; Structural and Functional Studies of Pavine N-Methyltransferase from Thalictrum flavum Reveal Novel Insights into Substrate Recognition and Catalytic Mechanism.; J.Biol.Chem., 291:23403-23415, 2016; PubMed: 27573242; DOI: 10.1074/jbc.M116.747261

実験手法

X-RAY DIFFRACTION (1.792 Å)