5KMM

TrkA JM-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-(1-naphthyl)urea

5KMM の概要

• エントリーDOI: 10.2210/pdb5kmm/pdb
• 関連するPDBエントリー: 5KMI 5KMJ 5KMK 5KML 5KMN 5KMO
• 分子名称: High affinity nerve growth factor receptor, 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-naphthalen-1-yl-urea (3 entities in total)
• 機能のキーワード: kinase, juxtamembrane, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane ; Single-pass type I membrane protein : P04629
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37621.15

構造登録者

Su, H.P. (登録日: 2016-06-27, 公開日: 2016-12-28, 最終更新日: 2023-09-27)

• 主引用文献: Su, H.P.,Rickert, K.,Burlein, C.,Narayan, K.,Bukhtiyarova, M.,Hurzy, D.M.,Stump, C.A.,Zhang, X.,Reid, J.,Krasowska-Zoladek, A.,Tummala, S.,Shipman, J.M.,Kornienko, M.,Lemaire, P.A.,Krosky, D.,Heller, A.,Achab, A.,Chamberlin, C.,Saradjian, P.,Sauvagnat, B.,Yang, X.,Ziebell, M.R.,Nickbarg, E.,Sanders, J.M.,Bilodeau, M.T.,Carroll, S.S.,Lumb, K.J.,Soisson, S.M.,Henze, D.A.,Cooke, A.J.; Structural characterization of nonactive site, TrkA-selective kinase inhibitors.; Proc. Natl. Acad. Sci. U.S.A., 114:E297-E306, 2017; PubMed: 28039433; DOI: 10.1073/pnas.1611577114

実験手法

X-RAY DIFFRACTION (2.12 Å)