5KKN

Crystal structure of human ACC2 BC domain in complex with ND-646, the primary amide of ND-630

5KKN の概要

• エントリーDOI: 10.2210/pdb5kkn/pdb
• 分子名称: Acetyl-CoA carboxylase 2, 2-[1-[(2~{R})-2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-bis(oxidanylidene)thieno[2,3-d]pyrimidin-3-yl]-2-methyl-propanamide (3 entities in total)
• 機能のキーワード: biotin-dependent carboxylase, grasp fold, lyase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Mitochondrion : O00763
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 121323.18

構造登録者

Wang, R.,Paul, D.,Tong, L. (登録日: 2016-06-22, 公開日: 2016-07-13, 最終更新日: 2024-03-06)

• 主引用文献: Harriman, G.,Greenwood, J.,Bhat, S.,Huang, X.,Wang, R.,Paul, D.,Tong, L.,Saha, A.K.,Westlin, W.F.,Kapeller, R.,Harwood, H.J.; Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.; Proc.Natl.Acad.Sci.USA, 113:E1796-E1805, 2016; PubMed: 26976583; DOI: 10.1073/pnas.1520686113

実験手法

X-RAY DIFFRACTION (2.6 Å)