5KK7

Crystal structure of the class I human endoplasmic reticulum 1,2-alpha-mannosidase T688A mutant and Thio-disaccharide substrate analog complex

5KK7 の概要

• エントリーDOI: 10.2210/pdb5kk7/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900033
• 分子名称: Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, alpha-D-mannopyranose-(1-2)-methyl 2-thio-alpha-D-mannopyranoside, CALCIUM ION, ... (8 entities in total)
• 機能のキーワード: alpha/alpha-barrel, cation replacement, protein-glycan interaction, hydrolase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Endoplasmic reticulum membrane ; Single-pass type II membrane protein : Q9UKM7
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 106710.03

構造登録者

Karaveg, K.,Xiang, Y.,Moremen, K.W. (登録日: 2016-06-21, 公開日: 2017-05-10, 最終更新日: 2020-07-29)

• 主引用文献: Xiang, Y.,Karaveg, K.,Moremen, K.W.; Substrate recognition and catalysis by GH47 alpha-mannosidases involved in Asn-linked glycan maturation in the mammalian secretory pathway.; Proc. Natl. Acad. Sci. U.S.A., 113:E7890-E7899, 2016; PubMed: 27856750; DOI: 10.1073/pnas.1611213113

実験手法

X-RAY DIFFRACTION (1.7324 Å)