5KI6
Human Argonaute-2 bound to a guide RNA with a nucleobase modification at position 1
Summary for 5KI6
Entry DOI | 10.2210/pdb5ki6/pdb |
Descriptor | Protein argonaute-2, miR-122, PHENOL, ... (4 entities in total) |
Functional Keywords | argonaute, mirna, rnai, hydrolase-rna complex, hydrolase/rna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 104561.70 |
Authors | Schirle, N.T.,MacRae, I.J. (deposition date: 2016-06-16, release date: 2016-07-20, Last modification date: 2023-09-27) |
Primary citation | Suter, S.R.,Sheu-Gruttadauria, J.,Schirle, N.T.,Valenzuela, R.,Ball-Jones, A.A.,Onizuka, K.,MacRae, I.J.,Beal, P.A. Structure-Guided Control of siRNA Off-Target Effects. J.Am.Chem.Soc., 138:8667-8669, 2016 Cited by PubMed: 27387838DOI: 10.1021/jacs.6b06137 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.153 Å) |
Structure validation
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