5KHU

Model of human Anaphase-promoting complex/Cyclosome (APC15 deletion mutant), in complex with the Mitotic checkpoint complex (APC/C-CDC20-MCC) based on cryo EM data at 4.8 Angstrom resolution

Summary for 5KHU

• Entry DOI: 10.2210/pdb5khu/pdb
• Related: 5KHR
• EMDB information: 4021 4025
• Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 13, Anaphase-promoting complex subunit 2, ... (17 entities in total)
• Functional Keywords: inhibition, cell cycle, mitosis, conformational change
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : Q9BS18 Q13257 P30260 Q8NHZ8; Cytoplasm: O60566 Q9NYG5 Q96DE5; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : Q12834 Q13042
• Total number of polymer chains: 23
• Total formula weight: 1408427.94

Authors

Yamaguchi, M.,VanderLinden, R.,Dube, P.,Stark, H.,Schulman, B. (deposition date: 2016-06-15, release date: 2016-09-07, Last modification date: 2024-03-06)

• Primary citation: Yamaguchi, M.,VanderLinden, R.,Weissmann, F.,Qiao, R.,Dube, P.,Brown, N.G.,Haselbach, D.,Zhang, W.,Sidhu, S.S.,Peters, J.M.,Stark, H.,Schulman, B.A.; Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation.; Mol.Cell, 63:593-607, 2016; PubMed: 27522463; DOI: 10.1016/j.molcel.2016.07.003

Experimental method

ELECTRON MICROSCOPY (4.8 Å)