5KH4

Crystal Structure of Steptococcus pneumoniae Undecaprenyl pyrophosphate Synthase (UPPS) with FARNESYL DIPHOSPHATE

5KH4 の概要

• エントリーDOI: 10.2210/pdb5kh4/pdb
• 分子名称: Isoprenyl transferase, FARNESYL DIPHOSPHATE (2 entities in total)
• 機能のキーワード: upps, native, bacterial, undecaprenyl s. pneumoniae, transferase
• 由来する生物種: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62587.06

構造登録者

Concha, N.O. (登録日: 2016-06-14, 公開日: 2016-07-20, 最終更新日: 2024-03-06)

• 主引用文献: Concha, N.,Huang, J.,Bai, X.,Benowitz, A.,Brady, P.,Grady, L.C.,Kryn, L.H.,Holmes, D.,Ingraham, K.,Jin, Q.,Pothier Kaushansky, L.,McCloskey, L.,Messer, J.A.,O'Keefe, H.,Patel, A.,Satz, A.L.,Sinnamon, R.H.,Schneck, J.,Skinner, S.R.,Summerfield, J.,Taylor, A.,Taylor, J.D.,Evindar, G.,Stavenger, R.A.; Discovery and Characterization of a Class of Pyrazole Inhibitors of Bacterial Undecaprenyl Pyrophosphate Synthase.; J.Med.Chem., 59:7299-7304, 2016; PubMed: 27379833; DOI: 10.1021/acs.jmedchem.6b00746

実験手法

X-RAY DIFFRACTION (3.2 Å)