5KE3

Crystal structure of SETDB1 Tudor domain in complex with fragment MRT0181a

5KE3 の概要

• エントリーDOI: 10.2210/pdb5ke3/pdb
• 分子名称: Histone-lysine N-methyltransferase SETDB1, (S)-N-(furan-2-ylmethyl)-1-(1,2,3,4-tetrahydroisoquinoline-3-carbonyl)piperidine-4-carboxamide, BETA-MERCAPTOETHANOL, ... (6 entities in total)
• 機能のキーワード: setdb1, tudor domain, structural genomics, structural genomics consortium, sgc, methyl-lysine, inhibitor, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: Q15047
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25717.58

構造登録者

Dong, A.,Iqbal, A.,Mader, P.,Dobrovetsky, E.,Ferreira de Freitas, R.,Walker, J.R.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Schapira, M.,Brown, P.J.,Structural Genomics Consortium (SGC) (登録日: 2016-06-09, 公開日: 2016-08-03, 最終更新日: 2023-09-27)

• 主引用文献: Iqbal, A.,Mader, P.,Dong, A.,Dobrovetsky, E.,Ferreira de Freitas, R.,Walker, J.R.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Schapira, M.,Brown, P.J.; Crystal structure of SETDB1 Tudor domain in complex with fragment MRT0181a; to be published,

実験手法

X-RAY DIFFRACTION (1.7 Å)