5KDF

Inorganic pyrophosphatase from Mycobacterium tuberculosis in complex with inhibitor 6 and inorganic pyrophosphate

Summary for 5KDF

• Entry DOI: 10.2210/pdb5kdf/pdb
• Related: 5KDE
• Descriptor: Inorganic pyrophosphatase, ~{N}2,~{N}2,~{N}4,~{N}4-tetramethyl-6-(1-phenylpyrrol-2-yl)-1,3,5-triazine-2,4-diamine, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: hydrolase, pyrophosphatase, drug target, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Cellular location: Cytoplasm : P9WI55
• Total number of polymer chains: 1
• Total formula weight: 20059.44

Authors

Pang, A.H.,Garzan, A.,Garneau-Tsodikova, S.,Tsodikov, O.V. (deposition date: 2016-06-08, release date: 2016-09-28, Last modification date: 2023-09-27)

• Primary citation: Pang, A.H.,Garzan, A.,Larsen, M.J.,McQuade, T.J.,Garneau-Tsodikova, S.,Tsodikov, O.V.; Discovery of Allosteric and Selective Inhibitors of Inorganic Pyrophosphatase from Mycobacterium tuberculosis.; ACS Chem. Biol., 11:3084-3092, 2016; PubMed: 27622287; DOI: 10.1021/acschembio.6b00510

Experimental method

X-RAY DIFFRACTION (2.45 Å)