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5KCX

Pim-1 kinase in Complex with a Selective N-substituted 7-azaindole Inhibitor

Summary for 5KCX
Entry DOI10.2210/pdb5kcx/pdb
DescriptorSerine/threonine-protein kinase pim-1, IMIDAZOLE, ACETATE ION, ... (5 entities in total)
Functional Keywordskinase, inhibitor, complex, transferase-inhibitor complex, transferase/inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationIsoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains1
Total formula weight34130.11
Authors
Mechin, I.,McLean, L.R.,Zhang, Y.,Wang, R. (deposition date: 2016-06-07, release date: 2017-07-19, Last modification date: 2024-03-06)
Primary citationBarberis, C.,Moorcroft, N.,Arendt, C.,Levit, M.,Moreno-Mazza, S.,Batchelor, J.,Mechin, I.,Majid, T.
Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors - Part I.
Bioorg. Med. Chem. Lett., 27:4730-4734, 2017
Cited by
PubMed: 28947155
DOI: 10.1016/j.bmcl.2017.08.069
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

217705

數據於2024-03-27公開中

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