5KBZ
Structure of the PksA Product Template domain in complex with a phosphopantetheine mimetic
Summary for 5KBZ
Entry DOI | 10.2210/pdb5kbz/pdb |
Related | 3hrr |
Descriptor | Noranthrone synthase, (14R)-14-hydroxy-15,15-dimethyl-1-[5-({[(5-methyl-1,2-oxazol-3-yl)methyl]sulfanyl}methyl)-1,2-oxazol-3-yl]-4,9,13-trioxo-2-thia-5,8,12-triazahexadecan-16-yl dihydrogen phosphate (3 entities in total) |
Functional Keywords | aflatoxin, polyketide synthase, polyketide, product template, dehydratase, double hot dog fold, cyclase, transcription |
Biological source | Aspergillus parasiticus |
Total number of polymer chains | 2 |
Total formula weight | 84367.51 |
Authors | Tsai, S.C.,Burkart, M.D.,Townsend, C.A.,Barajas, J.F.,Shakya, G.,Topper, C.L.,Moreno, G.,Jackson, D.R.,Rivera, H.,La Clair, J.J.,Vagstad, A. (deposition date: 2016-06-03, release date: 2017-05-10, Last modification date: 2023-09-27) |
Primary citation | Barajas, J.F.,Shakya, G.,Moreno, G.,Rivera, H.,Jackson, D.R.,Topper, C.L.,Vagstad, A.L.,La Clair, J.J.,Townsend, C.A.,Burkart, M.D.,Tsai, S.C. Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases. Proc. Natl. Acad. Sci. U.S.A., 114:E4142-E4148, 2017 Cited by PubMed: 28484029DOI: 10.1073/pnas.1609001114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.803 Å) |
Structure validation
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