5K9Q

Crystal structure of multidonor HV1-18-class broadly neutralizing Influenza A antibody 16.a.26 in complex with A/Hong Kong/1-4-MA21-1/1968 (H3N2) Hemagglutinin

Summary for 5K9Q

• Entry DOI: 10.2210/pdb5k9q/pdb
• Related: 5K9J 5K9K 5K9O
• Descriptor: Hemagglutinin HA1, Hemagglutinin HA2, 16.a.26 Heavy chain, ... (6 entities in total)
• Functional Keywords: hv1-18 (qxxv), multidonor, h5, universal influenza vaccine, immune system
• Biological source: Influenza A virus; More
• Cellular location: Virion membrane ; Single-pass type I membrane protein : Q91MA7 Q91MA7
• Total number of polymer chains: 24
• Total formula weight: 626606.30

Authors

Joyce, M.G.,Thomas, P.V.,Wheatley, A.K.,McDermott, A.B.,Mascola, J.R.,Kwong, P.D. (deposition date: 2016-06-01, release date: 2016-11-30, Last modification date: 2020-07-29)

• Primary citation: Joyce, M.G.,Wheatley, A.K.,Thomas, P.V.,Chuang, G.Y.,Soto, C.,Bailer, R.T.,Druz, A.,Georgiev, I.S.,Gillespie, R.A.,Kanekiyo, M.,Kong, W.P.,Leung, K.,Narpala, S.N.,Prabhakaran, M.S.,Yang, E.S.,Zhang, B.,Zhang, Y.,Asokan, M.,Boyington, J.C.,Bylund, T.,Darko, S.,Lees, C.R.,Ransier, A.,Shen, C.H.,Wang, L.,Whittle, J.R.,Wu, X.,Yassine, H.M.,Santos, C.,Matsuoka, Y.,Tsybovsky, Y.,Baxa, U.,Mullikin, J.C.,Subbarao, K.,Douek, D.C.,Graham, B.S.,Koup, R.A.,Ledgerwood, J.E.,Roederer, M.,Shapiro, L.,Kwong, P.D.,Mascola, J.R.,McDermott, A.B.; Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses.; Cell(Cambridge,Mass.), 166:609-623, 2016; PubMed: 27453470; DOI: 10.1016/j.cell.2016.06.043

Experimental method

X-RAY DIFFRACTION (2.503 Å)