5K69

Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 2 with carbapenem drug T224

Summary for 5K69

Entry DOI	10.2210/pdb5k69/pdb
Descriptor	L,D-transpeptidase 2, GLYCEROL, (2~{S},3~{R},4~{R})-4-(1~{H}-indol-3-ylsulfanyl)-3-methyl-2-[(2~{S},3~{S})-3-oxidanyl-1-oxidanylidene-butan-2-yl]-3,4-dihydro-2~{H}-pyrrole-5-carboxylic acid, ... (4 entities in total)
Functional Keywords	peptidase, igd_like domain, ykud domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	2
Total formula weight	87812.56
Authors	Lamichhane, G.,Ginell, S.L.,Kumar, P. (deposition date: 2016-05-24, release date: 2016-11-09, Last modification date: 2023-09-27)
Primary citation	Kumar, P.,Kaushik, A.,Lloyd, E.P.,Li, S.G.,Mattoo, R.,Ammerman, N.C.,Bell, D.T.,Perryman, A.L.,Zandi, T.A.,Ekins, S.,Ginell, S.L.,Townsend, C.A.,Freundlich, J.S.,Lamichhane, G. Non-classical transpeptidases yield insight into new antibacterials. Nat. Chem. Biol., 13:54-61, 2017 Cited by PubMed: 27820797 DOI: 10.1038/nchembio.2237 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.001 Å)

Structure validation